Attaining higher coverage rates will require additional influenza vaccination programs in schools, universities, and ethnic medical associations’ PI3K cancer clinics. In addition, wider use of recall and reminder systems can achieve higher coverage among children and adults recommended for influenza vaccination.10 A large percentage of travelers we surveyed became ill either during or within a week after travel (43%), which was similar to the findings of other studies.13–17 The prevalence of ILI among study participants and their companions was close to the prevalence

of diagnosed respiratory infections (7.8%) among returned travelers who visited GeoSentinel network clinics.17 Although the finding was not significant, our study showed that 9 of 11 travelers who developed ILI had not been vaccinated against influenza. A study showed a 25%–34% reduction in ILI prevalence among in-season vaccinated adults.16 Therefore, all travelers should be considered for pre-travel influenza vaccination (both seasonal and H1N1 influenza vaccine) to reduce their risk of infection.10,16 Regarding attitudes toward H5N1 AI, our study found that Asians, FB travelers, those working in occupations other than health care/animal care, and those

who did not seek pre-travel advice were less likely to recognize possible risk factors such as contact with farm animals and birds, and participating in slaughtering and cleaning poultry. Although the risk of H5N1 AI to US travelers is still low,18 clinicians should address avian influenza preventive RAD001 measures, especially among travelers to countries where avian influenza is prevalent in birds and humans. Many travelers are looking for new experiences and adventures, which can increase their risk of exposure to infectious diseases, including novel influenza strains.13–18 We found that many travelers

participated in unplanned activities during their travel, such as visiting rural areas, visiting food markets, and attending large gatherings; thus, clinicians should carefully review travelers’ trip itineraries with the expectation that they might change their plans Histone demethylase and consider the full range of potential activities and risks in the travel destination. Our study corroborated the findings of previous studies regarding the health-seeking behavior of travelers, showing that less than half of travelers reported seeking any type of pre-travel health advice,19–22 and approximately 30% were FB travelers. We found that the primary care practitioner was the most common source of pre-travel health advice among FB travelers, followed by the internet and friends or relatives. In addition, several studies, including our own, addressed the underutilization of travel health specialists for pre-travel health advice, compared with primary health care physicians.