It should be borne in mind that our study may have had several limitations. First, reporting ailments I-BET-762 ic50 per week instead of per day may have introduced a recall and reporting bias, resulting in an underestimation of the incidence of ailments. Secondly, we only included children and parents who received pre-travel health advice; as a consequence, the incidence rates of ailments may even be higher in children traveling without any form of pre-travel health advice. Skin problems and abdominal problems like diarrhea are frequently reported ailments

in children and their parents and show a high tendency to recur during travel. The majority of these ailments are mild but occasionally interfere with planned activities. Children in

the age group 12 to 18 years are at a greater risk of developing ailments during a stay in a (sub)tropical country and they should be actively 5-FU nmr informed about the health risks of traveling to the tropics. This study was financially supported by an unconditional grant of the Port of Rotterdam. We thank all health professionals at the Travel Clinic in Rotterdam for their co-operation and Henk Koene for his helpful assistance with data management. P.J.J. van Genderen received speaker’s fee and reimbursement from GlaxoSmithKline and Sanofi Pasteur MSD for attending symposia. D.O. received speaker’s fee and reimbursements from GlaxoSmithKline and Crucell and from GlaxoSmithKline for attending symposia. The other authors state they have no conflicts of interest to declare. “
“With the economic recovery gaining momentum, travel experts predict that tourism in all regions will increase in 2010 by an estimated 3% to 4%.1 This increase in travel is forecasted to exceed 5% in Africa, Asia, and the Middle East, where the risk

of acquiring meningococcal disease or becoming a carrier is higher.2 When evaluating the need for vaccination in travelers, particularly for those traveling to developing world countries, it is important to consider not only the incidence rate but also the impact of the respective infection (Figure 1).3 As an example, Exoribonuclease meningococcal disease is rarely reported in travelers, but the impact of this infection can be as devastating for travelers as for any other individual. With its rapid clinical course and narrow window for diagnosis, the potential for negative outcomes from meningococcal disease may be increased particularly in travelers to remote locations where access to adequate health care facilities and antibiotics is limited. There is an additional public health concern with meningococcal infection, as travelers who are carriers may spread the infection in the society back home.