52, p<0.01). 6MWD also showed strong correlation with physical component score on the SF-36 in all

groups (r=0.51, p<0.01). In multivariate analysis, hepatitis C remained an independent predictor of 6MWD improvement (p=0.048). There was a trend towards worse 6MWD in NASH recipients (p=0.06). At 1-month post-LT, only 5/46 (10.9%) of recipients were enrolled in a rehabilitation program and at 1-year none were participating. Conclusions: 6MWD is lower in male patients up to 1 year post-LT as compared to HC and CLD patients. Among LT recipients, male sex and NASH are associated with poorer 6-minute walk performance, which is a simple and inexpensive measure of functional performance that can be easily applied in clinical practice. A minority of LT recipients MK-2206 in vivo are enrolled in a rehabilitation program highlighting the opportunity for early lifestyle intervention to potentially improve functional capacity after LT. Disclosures: see more Josh Levitsky – Consulting: Transplant Genomics Inc; Grant/Research Support: Novartis; Speaking and Teaching: Gilead, Salix The following people have nothing to disclose: Sarah Uttal, Lisa B. VanWagner, Brittany Lapin, Amanda Jichlinkski, Joshua Lee, Madeleine Heldman,

Brian Poole, Tanvi Subramanian, Eduardo A. Bustamante, Suvai Gunasekaran, Christopher S. Tapia, Annapoorani Veerappan, She-Yan Wong Background/Aim: Among HCV LT recipients, older recipient age has been associated with graft loss, but the natural history of HCV among young (age <40y) adults undergoing LT is unknown. Using MELD-era UNOS data, we evaluated young HCV LT recipients and compared their outcomes to older age cohorts. Methods: All US adult HIV(-), HCV-positive LT recipients from 2002-2013 were included (N=25,968). Graft loss (re-LT or death) was estimated using the Kaplan-Meier method and the association between

recipient age and survival assessed with Cox regression. Results: Overall, recipients were 25% female, 70% White, with mean age of 54.5y. Recipients <40y (n=105, 0.4% 18-29y; n=459, 1.8% 30-39y) vs >40yrs, had higher % female (31 vs 24), mean MELD at LT (24 vs 20), % rejection (18 vs 10), and lower mean donor risk index clonidine (1.3 vs 1.4), and % HCC (11 vs 44). Overall, the 1-, 3-, and 5-yr graft loss rates were 23%, 32%, and 40%. Using 40+y cohort as reference (40% 5-y graft loss), 5-y graft loss was higher at 63% and 42% for recipient age cohorts 18-29 and 30-39y respectively (p<0.001) (Fig). In adjusted analysis, recipient age 19-29y had 81%(HR 1.81, CI 1.39-2.37, p<0.001) and 30-39 had 17%(1.17, 1.01-1.36, p=0.04) higher rate of graft loss. In recipients 18-29, 30-39 and 40+y, re-LT occurred in 10% 10% and 5%; HCV-related death in 22%, 21% and 13% (p<0.001 for both). Among patients <40y, recipient age/y (HR 0.95, CI: 0.94-0.98), donor age/y (1.02, 1.02-1.03), recipient female (1.39; 1.06-1.83), MELD at LT per point (1.02, 1.00-1.