GM has received research funding, advisory board payments and speaker payments from Gilead and research funding and speaker payments from Janssen. H LORD,1 C TRELOAR,2 E CAMA,2 J NEWLAND,2 MT LEVY1 1Liverpool Hospital UNSW, Sydney Australia, 2Centre for Social Research in Health, UNSW Australia Introduction: Chronic B Hepatitis Virus is characteriZed LBH589 solubility dmso by 5 distinct phases named by underlying patho-physiological mechanism. Recommended monitoring and therapy is tailored to each phase. We have observed that

patients seem unaware of this, do not appreciate the dynamic nature of chronic HBV nor the monitoring and treatment implications. Methods: 1. We examined HBV specific patient information resources of national and international hepatitis / government organizations to determine what content was presented (significant content ≥10% of total content or own paragraph). 2. A visual resource using metaphorical Hepatitis B Bear imagery and renamed HBV phases; Silent, Damage, Control, Escape and Clear was developed. 3. Patients were surveyed to determine their opinion of the phases presented in this way. 4. A video, “Understanding Hepatitis B” using actors, Bear imagery Sirolimus concentration and scenarios was developed and launched onto

YouTube. 5. An independently conducted qualitative and quantitative survey was conducted to evaluate the efficacy of the video in conveying information. Results: 1. 18

patient HBV information resources were examined; 100% included information on prevention/vaccination, 94% on routes of transmission, 89% on complications of HBV (cancer and cirrhosis), 56% on monitoring recommendations , 78% on therapy but only 6% mentioned the phases of HBV infection in a significant way. 2 and 3. The renamed phases and bear imagery were evaluated by patients in our clinic, who strongly agreed (77%) or agreed (23%) that the illustrations assisted their understanding of HBV phases. The majority (70%) did not find the images upsetting or confusing. 23% did, largely because of the damage phase, which was subsequently modified. 4 and 5. To date, the video has been watched by over 16,000 members of the public. 127 community members were evaluated on their knowledge before and after watching the 上海皓元 video. Correct understanding of the phases increased significantly after watching the video (14% to 60%). A majority (61%) of respondents found the bear pictures useful. Qualitative responses overwhelmingly supported the usefulness of the bear. Conclusion: This work provides evidence that the current health literacy resources of HBV do not address the important information of the phases and suggests a novel Hepatitis B Bear based resource as one solution. An App (see understandinghepatititisB.com) is being developed that may also assist.