Markers for HBV and HCV Ixazomib ic50 were sought using commercial enzyme-linked immunosorbent assay (ELISA). Serum levels of thrombopoietin were measured by commercial enzyme-linked immunosorbent assay (Quantikine, R & D Systems, Wiesbaden-Nordenstandt, Germany). Statistical analysis: Platelet count, TPO levels, and stage of liver fibrosis were obtained at the time

when patients were included in the study. Continuous variables were compared using the Student’s t-test or the Kruskal–Wallis test as appropriate. Differences in serum TPO levels between groups were evaluated using the Kruskal–Wallis test. Correlation among variables was performed with Pearson regression analysis. A P-value ≤ 0·05 was considered significant. Results: Thrombocytopenia was present in 21 patients (65,63 %), Mean platelet counts of patients with cirrhosis

(10.28 ± 3.5 × 104/μl) were significantly lower than those with fibrosis F1 (23.6 ± 13.8 × 104), F2 (15.45 ± 4.8 × 104), or F3 (14.10 ± 7.1 × 104; p < 0.05). Mean thrombopoietin FDA approved Drug Library chemical structure levels of patients with fibrosis F1 = 64.31 ± 32.94 pg/ml, F2 = 49.54 ± 16.24 pg/ml, F3 = 45.67 ± 10.92 pg/ml, and with cirrhosis = 39.17 ± 11.20 pg/ml. Mean thrombopoietin levels of patients with fibrosis F1 (64.31 ± 32.94 pg/ml) were significant higher than those in patients with fibrosis F2, F3, and cirrhosis (p = 0.004; p = 0.001: p < 0.001). Mean thrombopoietin levels of patients with fibrosis F2, F3, and cirrhosis were not significantly different (p > 0,05). Conclutions: The degree of liver fibrosis showed significant negative correlation to platelet counts (p < 0.001, r = −0.586). Thrombocytopenia are significantly more frequent in patients

with fibrosis F4 than in patients with early stage of liver fibrosis (stage 1 to 3; p = 0.001). Platelet counts showed a significant inverse relationship to stage of liver fibrosis (p = 0.001). Mean thrombopoietin levels are significantly higher in patients with fibrosis F1 than in patients with fibrosis F2 to F4 (F1 : F4, p < 0.001; F1 : F3, p = 0.001; F1 : F2, p = 0.004). Thrombopoietin levels showed significant positive correlation to platelet counts (p = 0.004, r = 0.496). Y-27632 nmr We suggest that as the disease progresses from mild fibrosis to cirrhosis, decreased production of thrombopoietin may contribute to the further development of thrombocytopenia in cirrhosis. Key Word(s): 1. Liver fibrosis; 2. Thrombopoietin; 3. Thrombocytopenia; 4. Chronic viral hepatitis Presenting Author: YANG BAI Additional Authors: YINGQIAO ZHU, XIADONG DU Corresponding Author: YINGQIAO ZHU Affiliations: Ultrasound, 1st Hospital, Jilin University, Ultrasound, 1st Hospital, Jilin University Objective: This study aimed to assess the diagnostic value of contrast-enhanced ultrasound and color Doppler ultrasound on focal fatty infiltration of the liver.