It is often noted that cognitive decline is one of the primary elements concerning the aging population. In recent years, researchers have focused on nonpharmacological interventions as a

way to alleviate deficits associated with cognitive decline. One of the most recent nonpharmacological interventions applied to individuals experiencing cognitive decline or cognitive impairment is a program of cognitive training (CT) (Zanetti et al. 1995; Loewenstein et al. 2004; Sitzer et al. 2006; Acevedo and Loewenstein 2007). Today, this type of procedure is used with individuals from varying populations; however, more historically this type of procedure was used with individuals experiencing traumatic brain injuries (TBI) and since Inhibitors,research,lifescience,medical has evolved more recently to be applied to individual’s experiencing cognitive declines related

to illnesses such as mild cognitive impairment (MCI) as well as individuals with more serious neurodegenerative Inhibitors,research,lifescience,medical afflictions, such as Alzheimer’s disease (AD) (Loewenstein et al. 2004; Cicerone et al. 2005; Cipriani et al. 2006; Farina et al. 2006; Sitzer et al. 2006). CT programs vary in their approach of application; the first strategies utilized with individuals experiencing cognitive decline are often ones that are compensatory in nature. Compensatory strategies, for example, involve developing plans to help individuals meet everyday requirements, such as remembering appointments, individual’s names, Inhibitors,research,lifescience,medical or basic self-grooming skills. Thus, compensatory procedures focus on identifying Inhibitors,research,lifescience,medical key areas of deficit and developing strategies and utilizing tools to remediate these deficits. This is in contrast to the restorative approach, where the focus is on holistic remediation through generalized stimulation of the brain (Sitzer et al. 2006). Inhibitors,research,lifescience,medical Restorative strategies, therefore, focus on creating a program of general cognitive stimulation (e.g., problem solving and creative activities) aimed at engaging the participant in various tasks that are designed to activate the “brain” generally, and as such, there are no particular tasks tailored to a participant’s specified deficit. Both CT approaches have been examined via meta-analytic c-Met inhibitor review, which

also demonstrated that restorative strategies were noted to be more effective (Sitzer et al. 2006). Specifically, the suggestion is that restorative programs offer significant benefits resulting in the greatest amount of change at posttraining evaluations in both cognitive and functional tasks (Sitzer et al. 2006). Previously, it has been noted that a reduction in one’s visuospatial (VS)/visuomotor (VM) ability can be an early identifier for the onset of a cognitive impairment such as AD (Tales et al. 2002; Tippett and Sergio 2006). Additionally, it can be shown that the brain is highly interconnected with identified bundles of nerve fibers, such as the inferior longitudinal fasciculus, inferior occipitofrontal fasciculus, and posterior thalamic radiation (Voineskos et al.