Am J Pathol 2010, in press. 42. Li F: Every single cell clones from cancer cell lines growing tumors in vivo may not invalidate the cancer stem cell concept. Mol Cells 2009, 27:491–492.PubMedCrossRef 43. Ling X, Bernacki RJ, Brattain MG, Li F: Induction of survivin expression by taxol (paclitaxel) is an early event which is independent on taxol-mediated G2/M arrest. J Biol Chem 2004, 279:15196–15203.PubMedCrossRef

44. Jatoi A, Dakhil SR, Foster NR, Ma C, Rowland KM Jr, Moore DF Jr, Jaslowski AJ, Thomas SP, Hauge MD, Flynn PJ, et al.: Bortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer: phase II results from the North Central Cancer Treatment Group (N044B). J Thorac Oncol 2008, 3:516–520.PubMedCrossRef 45. Chang H, Gao Y, Zhang JY, Shi F, Chen YZ: [Expression of survivin Tipifarnib price and NF-kappaB in peripheral T-cell lymphoma and its significance.]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008, 16:1079–1081.PubMed 46. Sato A, Oya M, Ito K, Mizuno R, Horiguchi Y, Umezawa K, Hayakawa M, Murai M: Survivin associates with cell proliferation in renal cancer cells: regulation of survivin expression by insulin-like growth factor-1, interferon-gamma and a novel NF-kappaB inhibitor. Int J Oncol 2006, 28:841–846.PubMed

47. Yang DT, Young KH, Kahl BS, Markovina S, Miyamoto S: Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma. Mol Cancer 2008, 7:40.PubMedCrossRef 48. Liu learn more Q, Hilsenbeck S, Gazitt Y: Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL. Blood 2003, 101:4078–4087.PubMedCrossRef 49. Ooi MG, Hayden PJ, Kotoula V, McMillin DW, Charalambous Olopatadine E, Daskalaki E, Raje NS, Munshi NC, Chauhan D, Hideshima T,

et al.: Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib. Clin Cancer Res 2009, 15:7153–7160.PubMedCrossRef 50. Hurt EM, Thomas SB, Peng B, Farrar WL: Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator. Cancer Biol Ther 2006, 5:1154–1160.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions XL carried out the experimental design, performed most of the experiments and organized data for manuscript. DC performed the rest of experiments and involved in results discussion and organization. AAC initiated bortezomib-related projects in our institute, helped experimental design and revised the manuscript. FL initiated the project, participated in experimental design and wrote the manuscript. All authors read and approved the final manuscript.