FASEB J. 2004;18:382–4.PubMed 17. Karapetsas A,

Giannakakis A, Pavlaki M, Panayiotidis M, Sandaltzopoulos R, Galanis A. Biochemical and molecular analysis of the interaction between ERK2 MAP kinase and hypoxia inducible factor-1α. Int J Biochem Cell Biol. 2011;43:1582–90.PubMed 18. Frede S, Stockmann C, Freitag P, Fandrey J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J. 2006;396:517–27.PubMedCentralPubMed 19. Sumbayev VV. PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling. Immunol Lett. 2008;115:126–30.PubMed 20. Nicholas SA, Sumbayev VV. The involvement of hypoxia-inducible factor 1α in Toll-like receptor 7/8-mediated inflammatory response. Cell Res. 2009;19:973–83.PubMed 21. Gibbs BF, Yasinska IM, Pchejetski D, Wyszynski EGFR inhibitor RW, Sumbayev VV. Differential control of hypoxia-inducible factor 1 activity during pro-inflammatory reactions of human haematopoietic cells

of myeloid lineage. Int J Biochem Cell Biol. 2012;44:1739–49.PubMed 22. Imtiyaz HZ, Simon MC. Hypoxia-inducible factors as essential regulators of inflammation. Curr Τοp Microbiol Immunol. 2010;345:105–20. selleck chemical 23. Zhou J, Schmid T, Brune B. Tumor necrosis factor-α causes accumulation of a ubiquitinated form of hypoxia inducible factor-1α through a nuclear factor-κB-dependent pathway. Mol Biol Cell. 2003;14:2216–25.PubMedCentralPubMed 24. Jung Y-J, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1β-mediated Ponatinib datasheet up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 2003;17:2115–7.PubMed 25. Silver IA. Tissue PO2 changes in acute inflammation. Adv Exp Med Biol. 1977;94:769–74.PubMed 26. Hong SW, Yoo JW, Kang HS, Kim S, Lee DK. HIF-1α-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses. Mol Cells. 2009;27:243–50.PubMed 27. Werth N, Beerlage C, Rosenberger C,

Yazdi AS, Edelmann M, Amr A, et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE. 2010;5:e11576.PubMedCentralPubMed 28. Zarember KA, Malech HL. HIF-1α: a master regulator of innate host defenses? J Clin Invest. 2005;115:1702–4.PubMedCentralPubMed 29. Bosco MC, Varesio L. Dendritic cell reprogramming by the hypoxic environment. Immunobiology. 2012;217:1241–9.PubMed 30. Kong T, Eltzschig HK, Karhausen J, Colgan SP, Shelley CS. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β2 integrin gene expression. Proc Natl Acad Sci USA. 2004;101:10440–5.PubMedCentralPubMed 31. Zhou J, Dehne N, Brüne B. Nitric oxide causes macrophage migration via the GSK872 cell line HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med. 2009;47:741–9.PubMed 32. Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, Rapisarda A, et al.