We created two receiver-operating curves (ROC), one ROC using the HFRAI scores at 01/01/2005, and the other using FRAX output of 10-year probabilities for hip fracture. The primary outcome was incident hip fracture in the subsequent four years. We computed the area under the curve (AUC) for each ROC. We used Mann-Whitney statistics to compare AUCs of the two ROCs. RESULTS: On 01/01/2005 13,457 subjects over
60 years were enrolled in the practice. 94 % (12.650) consented to the study, among which 1953 subjects had FNBMD DEXA scan within https://www.selleckchem.com/products/byl719.html the previous 2 years. In our 1700 TSA HDAC patients study group 62 patients (3.6 %) sustained a hip fracture between 01/01/2005 and 12/31/2008 (34 patients with known FNBMD and 28 patients without known FNBMD). AUC for HFRAI was 0.75, which was no different than AUC for FRAX of 0.71 (p = 0.19). CONCLUSION: In our selected cohort HFRAI seemed to be a comparable tool to FRAX in hip fracture risk stratification. The AUC trended higher for HFRAI but was no Navitoclax different than FRAX. Both tools
integrate several clinical risk factors in risk stratification which may explain the similarity in our results. P36 EFFECT OF LYCORED ON BIOCHEMICAL MARKERS FOR CARDIOVASCULAR PROTECTION AND OSTEOPOROSIS PROTECTION AT MENOPAUSE: A PARALLEL GROUP PLACEBO CONTROLLED DOUBLE BLIND SUPERIORITY RCT Meeta Meeta, MD, Tanvir Hospital, Hyderabad, A.P, India INTRODUCTION: LycoRed® contains bioactive lycopene in its natural bio-environment of associated phytonutrients as found naturally in the tomato. Lycopene has attracted considerable interest in recent years as an important phytochemical with a beneficial role in human health due to its potential as an anti-oxidant and anti-inflammatory therapeutic agent. Several recent studies have suggested that dietary lycopene is able to reduce the risk of cardiovascular diseases and osteoporosis. OBJECTIVES: To analyze the effect of LycoRed (lycopene) supplementation on biochemical markers for cardiovascular-protection and osteo-protection at menopause. MATERIAL AND METHODS: This multicentric study recruited 176 postmenopausal women at 19 centers across 12 cities
Phospholipase D1 in India. These women were randomly assigned to LycoRed or placebo supplementation. Ethical Committee clearance for the study was taken and informed consent was obtained from each subject prior to enrollment. Demographical details and menopausal symptoms were recorded using a questionnaire. Fasting blood samples were obtained from each subject to analyze blood lycopene levels, lipid markers, CAD marker i.e. High sensitivity C-reactive protein (hs-CRP) and bone markers [aminoterminal propeptide of type 1 procollagen (P1NP) and Beta C-terminal telopeptide (β-CTx-1)] at pre and post supplementation. RESULTS: Out of the 176 women recruited,108 filled the exclusion and inclusion criteria. 57 women in LycoRed group and 43 women in placebo group completed the RCT.