ResultsThe frequencies of TNFR2 (G/G) genotype and G allele were higher in the mothers with PE (n=154) compared to the control group (15.3% vs 4.1% and 37% vs 26.3%, respectively); furthermore, the difference reached statistical significance (P=0.002, odds ratio=4.9; 95% confidence interval: 1.69-17.4 and P=0.03, odds ratio=1.69; 95% confidence interval: 1.03-2.8, respectively).

In contrast, the fetal genotype and allele frequencies of this polymorphism had no effect on the risk of PE.

ConclusionsThe exon 6 polymorphism in TNFR2 (rs1061622) or a gene at proximity is associated specifically with PE at least in the Tunisian population and could increase the risk for PE for mothers carrying the homozygote minor allele. Nevertheless, these results need

GSK3326595 in vitro to be confirmed in other populations.”
“We Selleck JNJ-26481585 discuss the ability to perform fluorescent immunocytochemistry, following cell fixation, using a microfluidic array of primary, nonadherent, single CD34+ stem cells. The technique requires small cell samples and proceeds with no cell loss, making it well-suited to monitoring these rare patient-derived cells. The chip allows us to correlate live cell dynamics across arrays of individual cells with post-translational modifications of intracellular proteins, following their exposure to drug treatments. Results also show that due to the microfluidic environment, the time scale of cell fixation was significantly reduced compared to conventional methods, leading to greater confidence in the status of the protein modifications

studied. (C) 2011 American Institute of Physics. [doi:10.1063/1.3587095]“
“AimThis study was undertaken to determine the prevalence of post-partum urinary retention after vaginal delivery and to examine the associated risk factors.

Material and MethodsThis was a prospective observational MEK activation study carried out over a 2-month period at the major university teaching hospital in southwestern Nigeria.

ResultsPrevalence of post-partum urinary retention was 29.4%. The majority (93.3%) of women had covert urinary retention while 6.7% had overt urinary retention. From the bivariate analysis, episiotomy, reduced voiding desire and primiparity were risk factors for post-partum urinary retention (66.6% vs 30.6%; P=0.017; 47.75% vs 13.9%; P=0.037; and 60.0% vs 30.6%; P=0.05; respectively).

ConclusionPost-partum urinary retention, particularly covert retention, is a common complication of labor and delivery in our clinical practice but is rarely reported in the published work, especially from this part of the world. No factor has been found to be independently associated with its occurrence, hence there is need for vigilance in the immediate post-partum period as most cases of urinary retention would have been avoided if women were encouraged to void early following delivery.