Ensuring that such mapping is undertaken and interpreted in as transparent and robust a manner as possible is therefore crucial in allowing

regulators to accurately compare the clinical and cost effectiveness of new drugs across therapeutic areas.”
“In comparison with conventional structures, nanofibrous structures PD98059 ic50 have unique characteristics, such as higher surface-to-volume ratios, smaller pores, and higher porosity. Their hydrophilic nature is a key characteristic for many applications. However, because of their high porosity, it is difficult to measure the hydrophilicity of nanofibrous structures with contact-angle measurements. Therefore, characterization through wicking behavior is more appropriate. The International Organization for Standardization norm on wicking needs some refining to account for the specific nature of highly porous nanofibrous structures. A refined method was used on several structures that differed in the fiber diameter and the polyamide type. The structures with the thickest nanofibers had the highest wicking rates. selleck chemicals llc At equilibrium, the wicking heights of structures of different polyamide types with the same average fiber diameter followed the trend expected from their intrinsic hydrophilicity. In the initial

phase, the capillary forces established the wicking behavior. Later in the process, the wicking behavior was determined by the capillary forces and the hydrophilicity. In conclusion, the hydrophilicity of nanofibrous structures can be successfully determined by an optimized wicking procedure, and the fiber diameter is the dominant parameter for the resulting wicking height at equilibrium. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 305-310, 2011″
“The objective of the present study was to investigate the effect of the pellet core materials

isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different PF 00299804 ratios of Eudragit (R) RS30D and Eudragit (R) RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus. Physical characteristics such as mechanical strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I ( basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar- and isomalt-type pellet cores demonstrated similar drug release profiles.