Temperature and excitation density dependence of the exciton

resonances are investigated. Our experiments suggest that excitons are strongly confined in individual QDs instead of residing in all QDs in the cluster. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3369389]“
“The present investigation was undertaken to fabricate modified transport fluconazole transdermal spray using ethyl cellulose and EudragitA (R) RS100 as film-forming polymers. EudragitA (R) RS100 (X (1)) and ethyl cellulose (X (2)) were selected as independent variables in 3(2) full factorial design, whereas drug transport in first hour (Y (1)) and the time required for 50% drug transport (Y (2)) were selected as dependent variables. Eutectic blend of camphor and menthol was used as permeation enhancer cum solvent for film-forming polymers. The pH, viscosity, volume of solution PFTα in vitro delivered upon each actuation, spray angle, ex-in vivo physical evaluation and in vitro drug transport of the formulated products were evaluated. The optimized batch B16 containing 5.25% w/w ethyl cellulose and 10.6% w/w EudragitA (R) RS100 was formulated by overlapping the contour plots of Y (1) and Y (2). The pH, viscosity, volume of solution sprayed upon each actuation and spray angle of the batch B16 was 6.3, 52.9 cPs, 0.24 ml and 82.6A degrees respectively. The film of optimized batch was flexible and dermal-adhesive.

find more The responses Y (1) and Y (2) of batch B16 were 7.91 mu g/ml and 347 min respectively. The kinetics of drug transport was best explained AEB071 by the Korsmeyer and Peppas model. The eutectic mixture consisting of equal parts of camphor and menthol showed improved drug permeation through shed snake skin. Short-term stability study demonstrated insignificant changes in performance characteristics.”
“Methamphetamine (METH), a commonly abused psychostimulant, causes dopamine neurotoxicity in humans, rodents, and nonhuman primates. This study examined the selective neuroanatomical pattern of dopaminergic neurotoxicity induced by METH in the mouse striatum. We examined the effect of METH on tyrosine hydroxylase (TH) and dopamine transporter

(DAT) immunoreactivity in the different compartments of the striatum and in the nucleus accumbens. The levels of dopamine and its metabolites, 3,4-dihidroxyphenylacetic acid and homovanillic acid, as well as serotonin (5-HT) and its metabolite, 5-hydroxyindolacetic acid, were also quantified in the striatum. Mice were given three injections of METH (4 mg/kg, i.p.) at 3 h intervals and sacrificed 7 days later. This repeated METH injection induced a hyperthermic response and a decrease in striatal concentrations of dopamine and its metabolites without affecting 5-HT concentrations. In addition, the drug caused a reduction in TH- and DAT-immunoreactivity when compared to saline-treated animals. Interestingly, there was a significantly greater loss of TH- and DAT-immunoreactivity in striosomes than in the matrix.