5 These measures together have resulted in a very low residual risk for TTIs.6 Forskolin molecular weight Comparable results for TTIs risks are found in most developed countries. In Australia the risks are 1 in 633,000 units for HBV, 1 in 6,387,000 units for HCV and 1 in 9,242,000 units for HIV.7 The objective of pre-donation TTI testing is to save resources,

materials and man-hours which would have been spent to procure donor blood which could not be used in therapy and reduce the discard rate of donated blood. By performing pre-donation testing the infected prospective donor is spared the trouble of going through the donation process unnecessarily and the discard rate of donated blood is reduced. Pre-donation TTI testing is the standard practice in many Hospital-based blood transfusion services in developing countries like Nigeria. A major consumable for blood collection is the imported blood bag hence pre-donation testing and deferral of unsuitable prospective donor/s is assumed to produce substantial cost savings on procurement of blood bags. It appears www.selleckchem.com/products/ABT-263.html however that the basis for such assumption has not been clearly established.

All related financial costs and the implications for blood safety must be factored in to justify routine Pre-donation testing of blood donors. This study was carried out to establish whether or not Pre-donation testing affords substantial cost savings without compromise to blood safety. Materials and Methods In the University of Ilorin Teaching Hospital, pre-donation TTI testing is done after the all prospective donor has passed the haemoglobin check. Two rapid test systems are used to test for HIV, namely Determine and Unigold. The single rapid kit used for testing HBsAg is the ACON while Diaspot is used for testing HCV. Donation is deferred when the blood sample of a prospective donor is reactive for any of the TTI markers. Blood donated by donors found non-reactive on pre-donation TTI testing is later subjected in batches to routine Post-donation

ELISA testing for the three TTI markers. All records of Pre and Post-donation tests carried out in the donor clinic of University of Ilorin Teaching Hospital between January and December 2010 were reviewed. All processes and inputs were evaluated. Costs were calculated for Pre-donation testing by simple rapid techniques and Post-donation testing by ELISA for blood samples from all prospective donors. The compared costs were also computed for both Pre-donation testing of all prospective donors and Post-donation testing of blood samples of donors who eventually donated blood. All costs were compared. We also compared the number of samples that were reactive with rapid testing and the number that were reactive with ELISA. Rapid Test Kits DETERMINE (Inverness Medical Japan Co.