02). HER3 protein was more commonly overexpressed in nodular and infiltrative than in papillary tumors (P = 0.03). HER3 overexpression was associated with decreased survival in both univariate (P = 0.01) and multivariate (P = 0.008) analyses, whereas HER2 overexpression was not associated with survival. HER2 and HER3 are overexpressed in subsets of EHCC

patients. Notably, HER3 overexpression is correlated with decreased patient survival, suggesting that HER3 constitutes a prognostic factor as well as a potential candidate for targeted therapy.”
“The term “raptus melancholicus” is rarely used in clinical or scientific discussions. There is a lack of data on frequency and attribution to psychiatric disorders. It is found more often in the older literature where authors write of detailed personal experiences with this malicious phenomenon, but the published information is isolated as well. Clinicians and forensic GW3965 psychiatrists judge raptus melancholicus to represent a risk for suicidal attempts as it appears suddenly and unexpectedly, arising from a state of delayed and inhibited psychomotor motility. This enigma, which sounds quite paradoxical,

LBH589 requires a psychopathological explanation as offered here. The inclusion of forensic aspects suggests that raptus melancholicus is not such a rare entity.”
“This paper analyzes regional interdependencies and trajectories of the energy and agriculture sectors in Germany’s Northwest Metropolitan Region in order to assess the performance of regional low-cost and low-carbon strategies to alter energy sector profiles in the light of changing socioeconomic, technological and climate conditions. Our assessment is based on a dynamic, interactive simulation model for the years 2010 to 2050, which was developed and played out buy GSK1210151A in close collaboration with diverse stakeholder groups in the region. Results from the model and modeling exercises demonstrate the need to increase energy efficiency

because the reduction in demand it generates extends the policy space for decreasing emissions and reduces vulnerability to climate change. The results also show the feasibility of expanding renewable energy without heavy reliance on biomass, which currently is an important and contested source of energy in the region. (C) 2015 Elsevier B.V. All rights reserved.”
“Biennial breeding is a rare life-history trait observed in animal species living in harsh, unproductive environments. This reproductive pattern is thought to occur in 10 of 14 species in the genus Marmota, making marmots useful model organisms for studying its ecological and evolutionary implications. Biennial breeding in marmots has been described as an obligate pattern which evolved as a mechanism to mitigate the energetic costs of reproduction (Evolved Constraint hypothesis).