A continuum model is presented to study the frequency properties of the oscillator. The model is validated by the molecular dynamics simulations. (C) 2010 American Institute of Physics. [doi:10.1063/1.3481030]“
“Objective. The aim was to report the kinetics of masticatory muscles using a 4-dimensional muscle model and kinetically investigate the etiology Kinase Inhibitor Library purchase of square mandible (SQM) in vivo.
Study design. To ascertain the mandibular movements in patients with SQM, we compared a group of 11 SQM patients with painless limited mouth opening to a matched group of 11 healthy volunteers who acted
as control subjects. Mandibular movements were recorded using a 6-degrees-of-freedom jaw-tracking device, with the incisal and kinematic condylar as analytic points.
Results.
For the control group, mean tracking distance for the incisal point was 50.1 +/- 6.8 mm, whereas for the SQM group mean tracking distance was 27.1 +/- 2.8 mm. With lateral excursions, the control group’s mean tracking distance of the incisal point was 9.9 +/- 2.01 mm, and the SQM group’s was 8.1 +/- 1.64 mm.
Conclusion. Despite a sufficient lateral excursion, motion of the mandible was limited by some factors at opening and suggests that the mode of lateral movements Y-27632 chemical structure in SQM patients may differ slightly from those in healthy individuals. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:e75-e81)”
“Background: Ionizing radiation is used to treat many of cancers, however, it also produces unwanted side effect on normal tissues, such as radiodermatitis. We previously established an animal model for radiodermatitis, and found that X-ray irradiation induced the expression of ID3 in hairless mouse skin by cDNA microarray.
Objective: The aim of this study is to investigate the functional role of ID3 in X-ray irradiated keratinocytes.
Methods: Immunohistochemistry, RT-PCR and Western blot were performed to demonstrate the ID3 induction
by X-ray irradiation. HaCaT keratinocytes were transduced with the recombinant adenovirus expressing HA-ID3, and then effects on apoptosis were analyzed.
Results: X-ray irradiation increased markedly the ID3 protein level in epidermis of mouse selleck chemical skin. X-ray irradiation also induced the expression of ID3 in HaCaT keratinocytes cultured in vitro, at both mRNA and protein levels. When ID3 was overexpressed by recombinant adenovirus, apoptosis of keratinocytes were induced even in the absence of X-ray irradiation. Furthermore, overexpression of ID3 sensitized Xray-induced apoptosis. Interestingly, X-ray irradiation significantly reduced the endogenous beta-catenin level, which was related with induction of apoptosis. Similarly, overexpression of ID3 led to remarkable reduction in beta-catenin level.
Conclusion: These results suggest that ID3 plays a role as an apoptosis inducer in response to X-ray irradiation via the regulation of endogenous beta-catenin level. (C) 2010 Japanese Society for Investigative Dermatology.