A new finite Student’s-t mixture model (SMM) is proposed in this paper. Existing models do not explicitly incorporate the spatial relationships between pixels. First, our model exploits Dirichlet distribution and Dirichlet law to incorporate the local spatial constrains see more in an image. Secondly, we directly deal with the Student’s-t distribution in order to estimate the model parameters,

whereas, the Student’s-t distributions in previous models are represented as an infinite mixture of scaled Gaussians that lead to an increase in complexity. Finally, instead of using expectation maximization (EM) algorithm, the proposed method adopts the gradient method to minimize the higher bound on the data negative log-likelihood and to optimize the parameters. The proposed model is successfully compared to the state-of-the-art finite mixture models.

Numerical experiments are presented where the proposed model is tested on various simulated and real medical images.”
“In 1988, the World Health Assembly resolved to globally eradicate poliomyelitis. As part of a four-pronged strategy with establishment of enhanced surveillance, institution of national immunization days, strengthening routine immunization, and carrying-out mopping-up activities, oral poliovirus vaccine (OPV) was selected as the vaccine-of-choice for Selleck AZD2014 eradication. Massive OPV use decreased the number of polio-endemic countries from >125 countries in 1988 to only 3 in 2012 and led to a >99.9% decrease in polio incidence in the corresponding period. In this communication, we will discuss polio vaccination options to accelerate eradication, to mitigate the risks during the planned withdrawal of type 2 OPV, and to secure eradication for future generations.”
“Bone morphogenetic protein (BMP) is commonly used as an ICBG substitute for transforaminal lumbar interbody spine

fusion (TLIF). However, multiple recent reports have raised concerns regarding a substantial incidence of perioperative radiculopathy. Also, given the serious complications reported with anterior cervical BMP use, risks related to swelling and edema with TLIF need to be clarified. As TLIF related complications with rhBMP-2 selleck chemical have generally been reported in small series or isolated cases, without a clear denominator, actual complication rates are largely unknown. The purpose this study is to characterize perioperative complications and complication rates in a large consecutive series of TLIF procedures with rhBMP-2. We reviewed inpatient and outpatient medical records for a consecutive series of 204 patients [113 females, 91 males, mean age 49.3 (22-79) years] who underwent TLIF using rhBMP-2 between 2003 and 2007. Complications observed within a 3-month perioperative interval were categorized as to etiology and severity. Wound problems were delineated as wound infection, hematoma/seroma or persistent drainage/superficial dehiscence.