All four patients with tumor size greater than 8 cm had no tumor recurrence during 3 years of follow-up. The 3-, and 5-year DFS for patients with AFP ≤ or >400 ng/mL were 86.8%, 82.4%, and 86.8%, 72.4%, respectively (P > 0.05). The disease-free and overall survivals were not significantly different

among the selleckchem five AFP classes (≤20 ng/mL; 21–100 ng/mL; 101–200 ng/mL; 201–400 ng/mL; >400 ng/mL). Conclusion: Preopertative serum AFP level has no prognostic role in patients who underwent liver transplantation for HBV-associated HCC without vascular invasion. Although the accuracy and objectivity of the radiological imaging remains a problem, carefully studying the radiologic imaging is still regarded as a first-line test for selecting appropriate candidates for liver transplantation and predicting

tumor recurrence following liver transplantation in patients with HCC. Key Word(s): 1. HCC; 2. OLT; 3. alpha-fetoprotein; 4. vascular invasion; Alectinib mw Presenting Author: TAUFIQUE AHMED Additional Authors: GUAN HUEI LEE Corresponding Author: TAUFIQUE AHMED Affiliations: Khoo Teck Puat Hospital; National University Hospital (S) Objective: To identify causes of death on the liver transplant waiting list. Methods: Retrospective single centre observational study, including all adult patients placed on the transplant waiting list at National University Hospital Singapore between 2000–12. Data was collected on age, sex, ethnicity, aetiology, indication for transplant, length of time on list and cause of death. Results: 140 patients were placed on the waiting list during the time period. 51 (36.4%) of selleck chemicals llc patients were transplanted, 80 (57.1%) died, and 9 (6.5%) were taken of the list due to clinical

improvement. The 80 patients that died waited a mean of 160 days for transplant. The mean bilirubin was 164 μmol/L, PT 26.9s, albumin 28 g/dL, creatinine 107 μmol/L, platelet count of 94 × 109/L and MELD 23.2 at the time of listing. Common aetiologies for these patients included 32.5% hepatitis B, 20% cryptogenic, 15% alcohol, 11.25% autoimmune, 6.25% hepatitis C, 7.5% drug induced, 3.75% Wilsons disease and 3.75% for other causes. In terms of indications for listing 43.75% listed for decompensated chronic liver disease, 23.75% for HCC, 18.75% for flare of chronic hepatitis B, 11.25% for acute liver failure and 2.5% for other reasons. For cause of death 58.75% died from sepsis, 15% as a result of progressive HCC, 7.5% for GI bleed, 5% for raised intracranial pressure, 3.75% for multi organ failure, 6.25% for others and 3.75% the cause of death was not known. 63.2% of patients listed for HCC as indication for transplant died from progressive HCC. If those listed for HCC are taken out of the overall analysis, 67.2% of patients would have died from sepsis.