Cancer Sci 2010,101(2):293–299.PubMedCrossRef 58. Satelli A, Li S: Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci 2011,68(18):3033–3046.PubMedCentralPubMedCrossRef 59. Gil MP, Bohn E, O’Guin AK, Ramana CV, Levine B, Stark GR, Virgin HW, Schreiber RD: Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci USA 2001,98(12):6680–6685.PubMedCentralPubMedCrossRef 60. Qing Y, Stark GR: Alternative activation of STAT1 and STAT3 in response to interferon-gamma. J Biol Chem 2004,279(40):41679–41685.PubMedCrossRef 61. Ramana CV, Gil MP, Han Y, Ransohoff RM, Schreiber RD, Stark

GR: Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci USA 2001,98(12):6674–6679.PubMedCentralPubMedCrossRef 62. Selleckchem MLN2238 Kerr IM, Costa-Pereira AP, Lillemeier BF, Strobl B: Of JAKs, STATs, blind watchmakers, jeeps and trains. FEBS Lett 2003,546(1):1–5.PubMedCrossRef 63. Ihle JN, Kerr IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 1995,11(2):69–74.PubMedCrossRef 64. Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, Yoshikawa K, Akira

S, Takeda J: Keratinocyte-specific ablation of Stat3 exhibits impaired skin Fer-1 price remodeling, but does not affect skin morphogenesis. EMBO J 1999,18(17):4657–4668.PubMedCentralPubMedCrossRef Meloxicam 65. Lim CP, Phan TT, Lim IJ, Cao X: Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration. Oncogene 2006,25(39):5416–5425.PubMedCrossRef 66. Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X: Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol 2006,172(2):245–257.PubMedCentralPubMedCrossRef 67. Bhinge AA, Kim J, Euskirchen GM, Snyder M, Iyer VR: Mapping the chromosomal targets of STAT1 by Sequence Tag Analysis

of Genomic Enrichment (STAGE). Genome Res 2007,17(6):910–916.PubMedCentralPubMedCrossRef 68. Ramana CV, Kumar A, Enelow R: Stat1-independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts. Biochem Biophys Res Commun 2005,327(3):727–733.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions PK, LZ, MHL, SMD, and JML are responsible for the study design. PK, LZ and MHL, performed the experiments and collected the data. PK, LZ, MHL, FB, GL, MS, GW, SS, SMD, and JML participated in the data analysis and interpretation. PK, MHL, TCW, KK, SMD, and JML drafted the manuscript. All authors read and approved the final manuscript.”
“Introduction MicroRNAs (miRNAs) are endogenous non-coding RNAs (~22 nucleotides) that regulate gene expression at the post-transcriptional level.