Clin Cancer Res 2003, 9:4792–4801.PubMed 12. Lee SJ, Kim JG, Sohn SK, Chae YS, Moon JH, Kim SN, Bae HI, Chung HY, Yu W: No Association of Vascular Endothelial
MCC950 Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer. Cancer Res Treat 2009, 41:218–223.PubMedCrossRef 13. Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR: Carcinoma-associated fibroblasts Anlotinib clinical trial direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999, 59:5002–5011.PubMed 14. Bissell MJ, Radisky D: Putting tumours in context. Nat Rev Cancer 2001, 1:46–54.PubMedCrossRef 15. Polyak K, Haviv I, Campbell IG: Co-evolution of tumor cells and their microenvironment. Trends Genet 2009, 25:30–38.PubMedCrossRef 16. Hayward SW, Wang Y, Cao M, Hom YK, Zhang B, Grossfeld GD, Sudilovsky D, Cunha GR: Malignant MLN2238 supplier transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res 2001, 61:8135–8142.PubMed 17. Cheng N, Bhowmick NA, Chytil
A, Gorksa AE, Brown KA, Muraoka R, Arteaga CL, Neilson EG, Hayward SW, Moses HL: Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene 2005, 24:5053–5068.PubMedCrossRef 18. Cheng N, Chytil A, Shyr Y, Joly A, Moses HL: Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res 2007, 67:4869–4877.PubMedCrossRef 19. Noel A, De Pauw-Gillet
MC, Purnell G, Nusgens B, Lapiere CM, Foidart JM: Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. Br J Cancer 1993, 68:909–915.PubMedCrossRef 20. Guo X, Oshima H, Kitmura T, Taketo MM, Oshima Etofibrate M: Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. J Biol Chem 2008, 283:19864–19871.PubMedCrossRef 21. Gabbiani G, Kapanci Y, Barazzone P, Franke WW: Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist. Am J Pathol 1981, 104:206–216.PubMed 22. Strutz F, Okada H, Lo CW, Danoff T, Carone RL, Tomaszewski JE, Neilson EG: Identification and characterization of a fibroblast marker: FSP1. J Cell Biol 1995, 130:393–405.PubMedCrossRef 23. Iwano M, Fischer A, Okada H, Plieth D, Xue C, Danoff TM, Neilson EG: Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts. Mol Ther 2001, 3:149–159.PubMedCrossRef 24. Christiansen VJ, Jackson KW, Lee KN, McKee PA: Effect of fibroblast activation protein and [alpha]2-antiplasmin cleaving enzyme on collagen types I, III, and IV. Arch Biochem Biophys 2007, 457:177–186.PubMedCrossRef 25.