Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients’ Response to IV Iron with Elevated Ferritin (DRIVE) Study. J Am Soc Nephrol.

2007;18:97594.CrossRef 28. Beshara S, Sorensen J, JQ1 Lubberink M, Tolmachev V, Langstrom B, Antoni G, Danielson BG, Lundqvist H. Pharmacokinetics and red cell utilization find more of 52Fe/59Fe-labelled iron polymaltose in anaemic patients using positron emission tomography. Br J Haematol. 2003;120:853–9.PubMedCrossRef 29. Beshara S, Lundqvist H, Sundin J, Lubberink M, Tolmachev V, Valind S, Antoni G, Langstrom B, Danielson BG. Pharmacokinetics and red cell utilization of iron(III) hydroxide–sucrose complex in anaemic patients: a study using positron emission tomography. Br J Haematol. 1999;104:296–302.PubMedCrossRef 30. Huff RL, Elmlinger PJ, Garcia JF, Oda JM, Cockrell MC, Lawrence JH. Ferrokinetics in normal persons and in patients having various erythropoietic disorders. J Clin Invest. buy Linsitinib 1951;30:1512–26.PubMedCrossRef 31. Vaisman B, Fibach E, Konijn AM. Utilization of intracellular ferritin iron for hemoglobin synthesis in developing human erythroid precursors. Blood. 1997;90:831–8.PubMed 32. Ponka P. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood. 1997;89:1–25.PubMed 33. Leimberg MJ, Prus E, Konijn AM, Fibach E. Macrophages

function as a ferritin iron source for cultured human erythroid precursors. J Cell Biochem. 2008;103:1211–8.PubMedCrossRef 34. Coulon S, Dussiot M, Grapton

D, Maciel TT, Wang PH, Callens C, Tiwari MK, Agarwal S, Fricot A, Vandekerckhove J, Tamouza H, Zermati Y, Dichloromethane dehalogenase Ribeil JA, Djedaini K, Oruc Z, Pascal V, Courtois G, Arnulf B, Alyanakian MA, Mayeux P, Leanderson T, Benhamou M, Cogné M, Monteiro RC, Hermine O, Moura IC. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia. Nat Med. 2011;17:1456–65.PubMedCrossRef 35. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–23.PubMedCrossRef 36. Eschbach JW. Anemia management in chronic kidney disease: role of factors affecting epoetin responsiveness. J Am Soc Nephrol. 2002;13:1412–4.PubMedCrossRef 37. Otaki Y, Nakanishi T, Hasuike Y, Moriguchi R, Nanami M, Hama Y, Izumi M, Takamitsu Y. Defective regulation of iron transporters leading to iron excess in the polymorphonuclear leukocytes of patients on maintenance hemodialysis. Am J Kidney Dis. 2004;43:1030–9.PubMedCrossRef 38. Hasuike Y, Nonoguchi H, Ito K, Naka M, Kitamura R, Nanami M, Tokuyama M, Kida A, Otaki Y, Kuragano T, Nakanishi T. Interleukin-6 is a predictor of mortality in stable hemodialysis patients. Am J Nephrol. 2009;30:389–98.PubMedCrossRef 39. Ludwiczek S, Aigner E, Theurl I, Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood. 2003;101:4148–54.PubMedCrossRef 40.