For high risk infants and children ≤24 months of age at the beginning of the RSV season having the following congenital or acquired immunodeficiencies, the prevention of severe RSV disease using Palivizumab may be considered as follows: • Primary immunodeficiencies with predominantly T-cell dysfunctions including, but not limited to, SCID, DiGeorge syndrome, Wiskott–Aldrich syndrome, Ataxia Telangiectasia, etc. T-cell dysfunctions include decrease in T-lymphocytes, T-cell functions (such as decreased proliferative this website responses to PHA) or marked lymphopenia. The following diseases and conditions

are not included: auto-inflammatory diseases which do not require medication, abnormality of granulocytes or the complement system, and mild T-cell dysfunction (in the absence of lymphopenia or T-lymphcoytopenia). For systemic wasting diseases such as HIV infection, general physical conditions should Selleckchem Ganetespib also be considered. In patients with these diseases and conditions, some reports of fatal cases of severe RSV infection have appeared. For infants and children ≤24 months of age at the beginning of the RSV season having the following conditions and diseases, the prevention of severe RSV disease using Palivizumab may be considered: • Allogeneic hematopoietic stem cell transplantation

(HSCT) Organ transplants. There have been reports of severe RSV infections in solid organ transplant (SOT) recipients. For infants and children ≤24 months of age at the beginning of the RSV season receiving solid organ transplants, the prevention of severe RSV disease using Palivizumab may be considered: Both recipients of and candidates for HSCT (-)-p-Bromotetramisole Oxalate or SOT with significant organ dysfunction or immunosuppression are included in the above criteria. These patients are considered at high risk of severe RSV infection even though they are hospitalized. For infants and children ≤24 months of age at the beginning of the RSV season having either (1) or (2) below, the prevention of severe RSV disease using Palivizumab may be considered: (1) Use of corticosteroids, immunosuppressants, or biologics#1 for the following diseases: • Rheumatic

diseases (juvenile idiopathic arthritis, systemic lupus erythematosus and juvenile dermatomyositis etc), auto-inflammatory syndrome, inflammatory bowel disease, so on. #1: Including high-dose corticosteroid therapy (≥0.5 mg/kg prednisolone every other day for approximately four weeks or longer, excluding local treatments of inhalation, topical use or joint injection), immunosuppressants (azathioprine, methotrexate, mizoribine, mycophenolate mofetil, cyclophosphamide, cyclosporine, tacrolimus, everolimus, rapamycin, etc), and biologics (including cytokine inhibitors). #2: Pharmacokinetics and effectiveness of Palivizumab may differ in individual cases. Optimal doses and intervals between them should be decided individually. #3: The drug may be lost through urine.