Hip circumference was measured at the mid point of the gluteal region. Cardiovascular measures included peak oxygen consumption and resting blood pressure. Peak oxygen consumption was measured during a submaximal exercise test using a Modified Bruce protocol (ACSM 2000) with 12-lead electrocardiogram and with monitoring of blood pressure. The treadmill test DNA-PK inhibitor was terminated if the participant (i) reached his or her peak oxygen consumption or predicted maximum heart rate, (ii) indicated

that he or she could not continue the testing, (iii) had systolic blood pressure above 220 mmHg or diastolic blood pressure above 100 mmHg, or (iv) developed abnormal electrocardiographic changes. For sample size calculation, we adopted a 1% difference in HbA1c as clinically worthwhile because an increase of 1%

is associated with an 18% increase in the relative risk of cardiovascular disease in patients with Type 2 diabetes mellitus (Selvin et al 2004). Most studies in the systematic review by Irvine and Taylor (2009) reported a standard deviation of HbA1c between 1.0% and 1.7%. Therefore, we anticipated a standard deviation of 1.35%. A total of 30 patients per group would provide an 80% probability of detecting a difference of 1% in HbA1c at a two-sided 5% significance level, assuming a standard deviation of 1.35%. Therefore we sought to recruit 60 participants. All participants with follow-up data were

analysed according 4-Aminobutyrate aminotransferase to their group allocation, ie, using an intention-to-treat analysis. Baseline values of the various outcome parameters were carried forward ABT-199 concentration for the 11 participants who dropped out during the intervention. The difference in change from baseline to post-intervention between the aerobic exercise and progressive resistance exercise groups for each outcome was assessed using an independent t-test. Statistical significance was set at p < 0.05, so results are presented as a mean difference (95% CI). Five hundred and thirty patients diagnosed with Type 2 diabetes mellitus attending the Diabetes Centre at Singapore General Hospital were screened for eligibility between October 2003 and October 2004. Sixty-eight patients met the eligibility criteria, of whom 60 patients gave informed consent to participate in the study and were randomised, with 30 being allocated to each group. The flow of participants through the trial and reasons for exclusion are presented in Figure 1. The baseline characteristics of the participants who completed the study and those lost to follow-up are presented in Table 2. Both groups were comparable and the participants lost to follow-up were comparable to those who completed the study. Two physiotherapists with 3 years experience supervised the exercise sessions at the Physiotherapy Outpatient Department in Singapore General Hospital.