In 20 BD patients and controls neither parvovirus B19 DNA was detected nor bacterial DNA. Viral DNA of Epstein–Barr virus (EBV), cytomegalovirus (CMV) and human herpes virus (HHV)8 was detected more frequently Palbociclib ic50 in the BD group,

whereas HSV DNA was only found in the controls, indicating that stomatitis might be caused by HSV. Conclusion:  Although no significant association of BD was detected with a single pathogen, our findings suggest that detection of HSV DNA or Chlamydiae would rather argue against classic BD. Whether there is a discriminative potential of the tested immune mediators/receptors has to be elucidated in further studies. “
“This study was designed to evaluate iron deficiency as a predisposing factor for resistant Akt cancer oral aphthosis in patients with Behcet’s disease (BD). In a case control study 220 consecutive BD patients with oral aphthosis were enrolled.

All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group). Demographic and clinical characteristics of the disease, serum iron, total iron binding capacity and serum ferritin were determined in each patient. We used independent t-test and Mann–Whitney U-test to compare the quantitative variables and chi-square test for qualitative variables. Odds ratio (OR) and confidence interval at 95% (95% CI) were calculated for each item. There was no significant

difference between the two groups in demographics or clinical characteristics of the disease. We found iron deficiency in 72 patients (32.7%, 95% CI: 6.2), higher in the Case group than Control (39.2% vs. 30.1%; P = 0.17). Despite the higher frequency of iron deficiency in men (26.8% vs. 14.5%), the difference was not statistically significant (P = 0.09). Multivariate logistic regression analysis showed that none of the iron deficiency or sex variables could predict the development of resistant oral aphthosis. The OR for iron deficiency was 1.52 (95% CI: 0.81–2.86) and for male sex was 1.04 (95% CI: 0.56–1.91). Despite the higher frequency of iron deficiency in BD patients with resistant oral aphthosis, we were not able to attribute this resistance 3-mercaptopyruvate sulfurtransferase to this deficiency. “
“To estimate the prevalence of osteoarthritis (OA) of different joints in rural areas of Iran. From five villages of Tuyserkan County, 1565 individuals were randomly selected and were interviewed to complete the Community Oriented Programme for Control of the Rheumatic Diseases (COPCORD) Core Questionnaire. Among these cases 1192 cases with rheumatic complaints were examined by a rheumatologist and laboratory and radiology tests were performed if necessary for the diagnosis. Definition of OA in various joints, were based on American College of Rheumatology (ACR) criteria.