Individuals were excluded from the study if they had a history of a current psychotic disorder, a current neurological disease (current CNS opportunistic infections, current HIV-associated dementia, current neurological disorder unrelated to HIV, active syphilis, or head injury with loss of consciousness >30 min) or a current drug use disorder. Six individuals were hepatitis C virus (HCV) positive,

of Anti-cancer Compound Library cell line whom four had received anti-HCV treatment and three had cleared the virus. The other two were asymptomatic. Therefore, the effect of HCV as a predictor of cognitive impairment could not be tested. A total of 101 participants were enrolled in the study. All clinical and laboratory information was recorded coincident with the examination. Haemoglobin was recorded retrospectively and incomplete data were found for four patients. Therefore, 97 HIV-positive subjects were included in this analysis

Carfilzomib (see Table 1). All participants signed an informed consent form and the affiliated research institutions and their ethics committees approved the research protocol. All participants were examined with a standard NP battery including 14 individual NP measures (see Cysique et al. [22] for details). In addition, the DASS [24] was administered in order to measure mood status. Raw scores were transformed into standard Z-scores using the mean and SD for the HIV-negative controls as reference [23]. NP impairment was defined as follows: 2 SD below the control mean in at least

two neuropsychological measures [25]. Using this NP-impairment definition, we found that 37.1% of individuals were classified as ‘NP-impaired’ in the HIV-positive sample (36 of 97) and 6.7% in the control group (two of 30) (P=0.0015). SVMs attempt to separate two groups, A and B, based on a vector of n predictors [1]. The aim is to determine a vector and a constant γ such that for each of the data points xi belonging to group A, , while for data points xi belonging to group B, . When the sets A and B are not completely separable in this manner the method incorporates the errors in separation ξi for each data point. For data points xi belonging to A we assign the value yi=+1, while for xi in B we assign Grape seed extract the value yi=−1. Optimal separation of the two sets consisting of m data points in total is then achieved through the optimization problem where v is a tuning parameter. This problem is modified to include a measure of the number of predictor variables used in the model by penalizing nonzero values of each of the components of the vector w. This aspect is termed ‘feature selection’ so that the optimal solution of the SVM method balances the accuracy of prediction with choosing the fewest number of predictors from the initial set of n. The SVM method used, pq−SVM, was a modification of the Lagrangian Support Vector Machine (LSVM) method of Mangasarian and Musicant [26], incorporating feature selection [27].