Our previous studies have shown that indole-chalcone-based compounds targeting tubulin exhibited potential cytotoxicity to CRC cells. Herein, three new number of derivatives were systematically designed and synthesized to explore their structure-activity relationship (SAR) against CRC based on prior analysis. Among them, a representative fluorine-containing analog (FC116) exerted superior efficacy on HCT116 (IC50 = 4.52 nM) and CT26 (IC50 = 18.69 nM) cell lines, and HCT116-xenograft mice with cyst development inhibition rate of 65.96% (3 mg/kg). Of note, FC116 may also suppress the growth of organoid models (IC50 = 1.8-2.5 nM) and showed adenoma number inhibition rate of 76.25% at the dosage of 3 mg/kg in APCmin/+ mice. In terms of mechanism, FC116 could induce endoplasmic reticulum (ER) stress to produce excess reactive oxygen types (ROS), resulting in mitochondrial harm to advertise the apoptosis of CRC cells by concentrating on microtubules. Our outcomes support that indole-chalcone compounds are guaranteeing tubulin inhibitors and emphasize the potential of FC116 to fight CRC.Microbial biotransformation of Cr(VI) is a sustainable method to lessen Cr(VI) poisoning and remediate Cr(VI) contamination. In this study, Bacillus cereus SES utilizing the convenience of reducing both Cr(VI) and Se(IV) ended up being isolated, plus the effectation of Se supplementation on Cr(VI) reduction by Bacillus cereus SES was examined. Se(IV) inclusion allowed 2.6-fold faster Cr(VI) decrease, while B. cereus SES paid off 96.96percent Se(IV) and produced even more selenium nanoparticles (SeNPs) within the presence of Cr(VI). Co-reduction items of B. cereus SES on Cr(VI) and Se(IV) had been SeNPs adsorbed with Cr(III). The relevant systems were see more further revealed by proteomics. Se(IV) supplementation mediated the formation of Cr(VI) reductants and stress-resistant substances, thus boosting Cr(VI) opposition and promoting Cr(VI) decrease. Meanwhile, large Se(IV) decrease rate had been involving Cr(VI)-induced electron transport procedures, and Cr(VI) mediated the up-regulation of flagellar system, protein export and ABC transporters paths to synthesis and export more SeNPs. Moreover, Se along with B. cereus SES had the possibility to lessen the poisoning of Cr(VI) via decreasing the bioavailability of Cr and improving the bioavailability of Se in soil. Results suggested that Se could be a simple yet effective technique to enhance the remediation of B. cereus SES on Cr contamination.In modern-day business, selective extraction and data recovery of Cu from highly acid electroplating effluent are very important to reduce carbon emissions, alleviate resource scarcity, and mitigate water air pollution, yielding substantial financial and environmental benefits. This research proposed a high-efficiency CuSe electrode to selectively eliminate Cu from electroplating effluent via hybrid capacitive deionization (HCDI). The potential of the electrode had been completely assessed to assess its effectiveness. The CuSe electrode exhibited superior deionization overall performance with regards to Cu adsorption capacity, selectivity, and applicability in various liquid matrices. Specifically, under strong acid circumstances (1 M H+), the CuSe electrode maintained an optimal adsorption ability of 357.36 mg g-1 toward Cu2+. In methods containing sodium ions, heavy metals, and actual electroplating wastewater, the CuSe electrode attained an amazing elimination performance as high as 90% for Cu2+ with a high distribution coefficient Kd. Particularly, the capacitive deionization (CDI) system demonstrated the multiple removal of Cu-EDTA. The elimination mechanism was additional disclosed making use of ex-situ X-ray diffraction and X-ray photoelectron spectroscopy analyses. Overall, this study presents a practical method that stretches the abilities of CDI systems for effectively eliminating and recovering Cu from acidic electroplating effluent.In this research, machine discovering models predicted the impact of silver nanoparticles (AgNPs) on soil enzymes. Artificial neural system (ANN) optimized with hereditary algorithm (GA) (MAE = 0.1174) was considerably better for simulating general trends, even though the gradient boosting machine (GBM) and arbitrary forest (RF) had been well suited for minor evaluation. In accordance with limited dependency profile (PDP) analysis, polyvinylpyrrolidone coated AgNPs (PVP-AgNPs) had probably the most inhibitory effect (average of 49.5%) on soil enzyme task among the list of three types of AgNPs in the exact same dose (0.02-50 mg/kg). The ANN model predicted that enzyme task initially declined and then rose when AgNPs increased in dimensions. Based on predictions through the ANN and RF designs, whenever exposed to uncoated AgNPs, soil chemical activities proceeded to decrease before 30 d, but slowly rose from 30 to 90 d, and dropped slightly after 90 d. The ANN model suggested the importance purchase of four facets dose > type > size > publicity time. The RF model proposed the enzyme ended up being much more sensitive when Nucleic Acid Analysis experiments were carried out at amounts, sizes, and visibility times during the 0.01-1 mg/kg, 50-100 nm, and 30-90 d, respectively. This research presents brand-new ideas from the regularity of earth chemical responses to AgNPs.Accurate description of Cd micro-zone circulation and accumulation may be the prerequisite for exposing Cd transfer and change procedures. But, to date, the part of soil pores into the Cd micro-zone distribution qualities in undisturbed earth is still confusing. In this study, the most obvious heterogeneous circulation of Cd close to the soil pores at the cross-sectional surface for the exotic undisturbed topsoil was visualized by the mix of X-ray micro-computed tomography and scanning electron microscope-energy dispersive spectroscopy. For both the air space and water-holding pores, the micro-zone circulation characteristics of Cd round the pores had been dominated by pore sizes. For macropores and mesopores, Cd preferred to circulate within the micro-zone within 167.5-335 µm from skin pores quinoline-degrading bioreactor . However for micropores, the highest content percentage of Cd was exhibited when you look at the micro-zone within 67-167.5 µm from skin pores.