Likewise, an increase in uric acid in all groups after the periodization protocol was observed, which was only statistically significant in the GC group. This fact has been widely described in a number of studies showing that plasma uric acid levels rise in ischemia-reperfusion events. The elevation in uric acid buy IWP-2 concentration suggests the occurrence of ischemia-reperfusion syndrome induced by resistance training and the consequent

free radical production. Actually, McBride et al. [13] suggest that muscle check details contraction caused by excessive resistance exercise may result in ischemia-reperfusion in active muscles. Moreover, high-intensity physical activity was observed to promote ATP degradation, with consequent plasma hypoxanthine and uric acid increase. However, TAS values suggested a significant reduction in antioxidant defense in the GC group compared to the other groups. In this sense,

significant strength gains in group GC may selleck products have promoted an increase in the energy production mechanism owing to the large capacity for ATP resynthesis in cells under Cr supplementation. This situation may be favorable for the manifestation of ischemia-reperfusion syndrome, with increased uric acid and hydroxyl radical production causing the mobilization of antioxidant reserves – thereby reducing TAS – to prevent oxidative stress. These results conflict with those presented by Guézennec

et al. [35], Adenosine triphosphate who suggested that Cr supplementation results in decreased hypoxanthine and urate production, as indicated by the reduction of ammonia concentration and increased performance. In this respect, these authors concluded that Cr supplementation had a sparing effect on purines. Likewise, Souza Júnior and Pereira [36] suggested that Cr may act as an energy buffer, either indirectly via increased intracellular phosphocreatine concentration, which may lessen formation of ATP degradation products, or because of the direct effects of arginine found in its molecular structure. However, we believe that even if Cr plays a role preventing ATP depletion, the energy production required for intense muscle activity will always be maximal and thus exacerbate purine degradation, since increasing the capacity for ATP resynthesis through Cr supplementation would make more ATP available for degradation. We believe that Cr supplementation boosts energy production and consequently increases hypoxanthine formation, resulting in free radical production, which in turn promotes consumption of antioxidant reserves. Conclusion We conclude that Cr supplementation associated to a specific resistance program promotes a significant increase in muscular strength without changes in body composition.