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“Background

Creatine is predominantly situated in skeletal muscle, and originates Tenofovir manufacturer from both endogenous de novo synthesis and exogenous sources, which are mainly animal products [1]. Creatine and its phosphorylated form are well recognized as key intermediates in the energy metabolism of muscle fibres. Supplementation of creatine has been widely used among athletes as a means for increasing muscle mass and muscle strength and muscle endurance [2–4], but also for elderly people creatine supplementation, seems to enhance muscle strength [5]. The rationale behind CMH supplementation is to increase the content of creatine phosphate in the muscle, and several studies have also shown that the creatine content of the muscle is increased [6], and the majority of this is as creatine phosphate [1, 2].