Results: Soluble endothelial protein C receptor levels did not indicate any significant difference between pre- and posttransplantation period, and sEPCR levels showed a significantly negative correlation between IL-6 and IL-8 (sEPCR and IL-6, r = -.43, P < .01; sEPCR and IL-8, r = -.57, P < .01). There was no correlation between sEPCR levels and TNF-alpha, SN-38 clinical trial IL-1 beta, or IL-2 (sEPCR and TNF-alpha, r = -.13, P > .05; sEPCR and IL-1 beta, r = -.1, P >= .05; sEPCR and IL-2, r = -.07, P > .05).

Conclusions: Our results suggest that the production

of sEPCR was not affected by allogeneic HSCT. Soluble endothelial protein C receptor did not show any positive correlation between these proinflammatory cytokines (TNF-alpha, IL-1 beta, IL-2, IL-6, and IL-8), on the contrary a significantly negative correlation was determined between sEPCR and either IL-6 or IL-8. This negative correlation may be a protective mechanism in the pathway of protein C activation.”
“Nodule CO2 fixation

is of pivotal importance for N-2 fixation. The process provides malate for bacteroids and oxaloacetate CSF-1R inhibitor for nitrogen assimilation. The hypothesis of the present paper was that grain legume nodules would adapt to higher plant N demand and more restricted carbon availability at pod formation through GSK2126458 nmr increased nodule CO2 fixation and a more efficient N-2 fixation. Growth, N-2 fixation, and nodule composition during vegetative growth and at pod formation were studied in pea plants (Pisum sativum L.). In parallel experiments, N-15(2) and (CO2)-C-13 uptake, as well as nodule hydrogen and CO2 release, was measured. Plants at pod formation showed higher growth rates and N-2 fixation per plant when compared with vegetative growth. The specific activity of active nodules

was about 25% higher at pod formation. The higher nodule activity was accompanied by higher amino acid concentration in nodules and xylem sap with a higher share of asparagine. Nodule (CO2)-C-13 fixation was increased at pod formation, both per plant and per N-15(2) fixed unit. However, malate concentration in nodules was only 40% of that during vegetative growth and succinate was no longer detectable. The data indicate that increased N-2 fixation at pod formation is connected with strongly increased nodule CO2 fixation. While the sugar concentration in nodules at pod formation was not altered, the concentration of organic acids, namely malate and succinate, was significantly lower. It is concluded that strategies to improve the capability of nodules to fix CO2 and form organic acids might prolong intensive N-2 fixation into the later stages of pod formation and pod filling in grain legumes.