Specifically, cadmium, lead and arsenic smoke deliveries for this cigarette under ISO smoking regime were 34.6 ± 3.2, 12.3 ± 1.1 and 3.05 ± 0.35 ng/cigarette respectively, in line with a recently organized ring trial results [38]. Dabrafenib concentration In one Korean brand, nicotine was reported as below limit of quantification (LOQ) in analyses under the ISO machine-smoking regime. This sample

was removed from the data set since the assessment of nicotine transfer was part of the data analysis. Only 267 data points were thus available for the smoke yields obtained under the ISO machine-smoking regime, while 567 data points were considered for the analysis of smoke yields obtained under the HCI machine-smoking regime. Data below the limits

of quantification were reported as Z-VAD-FMK in vitro sample. All measured values were above LOQ. Descriptive statistics for the results are presented in Table 2, together with a range of typical mean values reported in previously published surveys. Nicotine levels were also measured since nicotine transfer was required for the assessment of the elements transfer. Smoke yields of arsenic, cadmium, lead and nicotine were measured for each sample under

HCI machine-smoking regime. In addition, the yields under ISO machine smoking regime were also obtained from a subset of the samples (267 retained for the study). Unlike the filler levels, these smoke yields were below the analytical limit of quantification for many samples, Chloroambucil especially when the samples were smoked under ISO. The numbers of samples with levels determined below the limit of quantification are highlighted alongside the descriptive statistics in Table 3 (ISO yields) and Table 4 (HCI yields). Because samples with yields below LOQ were attributed the LOQ value in the calculation of medians and quartiles, some of the statistical data in Table 3 and Table 4 are reported as