The author diagnosed the tumor as malignant myoepithelioma, as myoepithelial markers (C10, p63, S100 protein, alpha-smooth muscle actin, caldesmon) were positive, and also because there was a transition between the tumor cells and myoepithelium of non-tumorous ducts. The grade of the tumor was high. The patient was treated with chemoradiation and was free of disease 5 months after the operation.”
“Objective: To investigate whether a topographic correlation exists between beta-zone parapapillary atrophy (PPA) and retinal nerve fiber layer (RNFL) defect. The location and extent of the beta-zone were examined.\n\nDesign:

Retrospective, cross-sectional study.\n\nParticipants: One hundred twenty-eight eyes from 128 consecutive patients with primary open-angle glaucoma (POAG) and a single localized RNFL defect were Blebbistatin cell line included.\n\nMethods: Digital optic disc photographs of the enrolled eyes were reviewed and eyes with beta-zone PPA were identified. The topographic parameters of beta-zone PPA and RNFL defect were measured on optic disc photographs find more and digital red-free RNFL photographs. The association between these parameters was examined statistically.\n\nMain Outcome Measures: Angular location

and angular extent of beta-zone PPA and RNFL defect, angular location of point of maximum radial extent (PMRE) of beta-zone PPA, and beta-zone PPA-to-disc area ratio.\n\nResults: Eighty-two (64.1%) of the 128 eyes with a single localized RNFL defect had beta-zone PPA. Patients selleck chemical with beta-zone PPA were younger (by 6.6 years) than those without beta-zone PPA (P = 0.001). beta-Zone PPA was located most commonly inferotemporally (65.9%). The RNFL defect was located in the same hemifield as the beta-zone PPA in 76% of eyes and was located in the same hemifield as PMRE in 88% of eyes. The angular location of the RNFL defect showed a linear correlation with

those of beta-zone PPA (r = 0.390; P < 0.001) and PMRE (r = 0.558; P < 0.001). The angular extent of RNFL defect was not correlated significantly with that of beta-zone PPA (P = 0.106), but it was associated weakly with beta-zone PPA-to-disc area ratio (r = 0.197; P = 0.026). The angular extent of the RNFL defect also was correlated with the cup-to-disc ratio (r = 0.322; P < 0.001) and the cup-to-disc area ratio (r = 0.337; P = 0.002).\n\nConclusions: In POAG, a localized RNFL defect is correlated spatially with beta-zone PPA.\n\nFinancial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2013;120: 528-534 (C) 2013 by the American Academy of Ophthalmology.