The combination of oppositely charged polymers in different ratios proved to be useful in modulating the rheological properties of the hydrated formulations and their release-retarding properties. Dynamic moduli can be used to measure gel strength and are significant for the interpretation of oral sustained release spray-dried complexes.”
“The relationship between the scratch resistance and the injection molding-induced morphology of polypropylene

(PP) was investigated. The crystal structure buy GW2580 near the surface was controlled by the mold temperature and the doping of a nucleating agent (NA). Although alpha- and beta-NA were used to improve the scratch resistance of PP that was molded at a mold temperature of 40 degrees C, both of the NAs only slightly affected the scratch resistance due to low crystallinity at the surface. When the mold temperature was increased, the skin layer became thin and a beta-form crystal formed. Plastic deformation under the scratch was limited in the frozen layer. Consequently, the thickness of the frozen layer (which had low crystallinity) had the predominant

effect on the scratch resistance in comparison to the polymorphism differences. The crystal morphology was analyzed with synchrotron micro-beam wide angle X-ray diffraction and Fourier transform infrared spectroscopy. (C) 2010 Wiley Periodicals, Inc. J Appl selleck chemicals Polym Sci 120: 141-147, selleck kinase inhibitor 2011″
“Patients with beta-thalassaemia, sickle cell disease (SCD) and myelodysplastic syndromes (MDS) require chronic blood transfusions, which can lead to iron overload and substantial morbiditY and mortality. To reduce the excess iron and its deleterious effects, available iron chelation therapy (ICT) in the US includes oral deferasirox

or infusional deferoxamine (DFO). The aim of this study was to review and synthesize the available pharmacoeconomic evidence on ICT in patients with beta-thalassaemia, SCD and MDS in the US.

We systematically identified and reviewed pharmacoeconomic studies of ICT in patients with beta-thalassaemia, SCD and MDS that either were published in MEDLINE-indexed, English-language journals from 1999 to 2009, or appeared in medical society websites and scientific meeting abstracts. We assessed available cost-of-illness, cost-of-treatment, cost-consequence, cost-effectiveness, utility and patient-satisfaction studies.

The majority of the 20 identified studies assessed cost of treatment, mainly focusing on acquisition and administration costs of ICTs. Gaps in the published literature include current data on direct medical costs for patients with MDS, direct medical costs associated with complications of iron overload, direct non-medical costs, indirect costs and patient utilities.