The long-term results regarding GSK2126458 clinical trial recurrence are limited, with most series reporting a mean follow-up between 12 and 24 months. Feasibility of diagnostic laparoscopy is ranging from 60% to 100% whilst therapeutic effectiveness of the laparoscopic approach is lower (40-88%). Predictive factors for successful laparoscopic adhesiolysis are: number of previous laparotomies ≤2, non-median previous laparotomy, appendectomy as previous surgical treatment causing adherences, unique band adhesion as pathogenetic mechanism of small bowel obstruction, early laparoscopic management within 24 hours from the onset of symptoms, no signs of peritonitis on physical examination, experience of the surgeon [68, 69]. Surgical operating time is

greater in patients who underwent laparoscopic surgery compared to patients who underwent a laparotomy [70, 71]. Postoperative morbidity is lower in patients who underwent laparoscopic adhesiolysis compared to those who underwent the laparotomic

approach. Furthermore a greater rate of morbidity is present in patients who underwent laparotomic conversion; whereas mortality is comparable in the two groups (0-4%). Finally the laparoscopic adhesiolysis can avoid laparotomy, which is itself a cause of new adhesions and bowel obstruction, although some authors noticed a greater incidence of recurrent small bowel obstructions in patients Selumetinib who underwent laparoscopy compared to those in which a laparotomy was performed [72, 73]. Operative technique has a capital role for a successful laparoscopic treatment [52]. The initial trocar should be placed away (alternative site technique) from the scars in an attempt to avoid adhesions. Some investigators have recommended the use of computed tomography scan or ultrasonography to help determine a safe site for the initial trocar insertion. The left upper quadrant or the left flank are usually the safest safe place to gain access to the abdominal cavity. Alternatively a 10 mm port can be inserted in the left flank with two additional 5 mm ports in the left upper and lower quadrant (or 10 mm and 5 mm respectively) [74]. Therefore, by triangulating 3 ports aimed at the right lower quadrant, a good exposure and access to

the right iliac fossa can be obtained and ID-8 a technique running the small bowel in a retrograde fashion, starting from the ileocecal valve (decompressed intestine) proximally towards the transition point between collapsed and dilated loops. The open (Hasson) approach under direct vision is the more prudent. Once safe access is obtained, the next goal is to provide adequate visualization in order to insert the remaining trocars. This often requires some SBE-��-CD concentration degree of adhesiolysis along the anterior abdominal wall. Numerous techniques are available, including finger dissection through the initial trocar site and using the camera to bluntly dissect the adhesions. Sometimes, gentle retraction on the adhesions will separate the tissue planes. Most often sharp adhesiolysis is required.