The patients were categorized learn more by mode of antiplatelet therapy (single [n = 64] or dual [n = 90]), neck size (wide [n = 80] or narrow [n = 74]), and technique used (simple [n = 42] or adjunctive [n = 112]). The incidences of hemorrhagic/ischemic complications and abnormalities on postprocedural diffusion-weighted magnetic resonance imaging (DWI) in each group were statistically assessed. Results: Hemorrhagic complications occurred in 1 case (1.5%) with single antiplatelet therapy and in 2 cases (2.2%) with dual antiplatelet therapy. Symptomatic ischemic complications

occurred in 5 cases (7.8%) with single therapy and in 4 cases (4.4%) with dual therapy. Abnormalities were detected by DWI in 27 cases (42%) with single

therapy and in 31 cases (34%) with dual therapy. No significant difference was found between modes of antiplatelet therapy even when the technique used was taken into account. In cases of wide neck, however, there were significant differences in the rate of symptomatic ischemic complications (single, 21.7%; dual, 3.5%; P = .014) and DWI abnormalities (single, 37.8%; dual, 20.9%; P = .048). Conclusion: Our data suggest that dual antiplatelet therapy may better prevent ischemic complications from coiling PLX4032 research buy for wide-necked aneurysms compared with single antiplatelet therapy.”
“BACKGROUND: Levobupivacaine, the S(-) isomer of bupivacaine, is less cardiotoxic than racemic bupivacaine. Previous studies have examined different concentrations of levobupivacaine in similar ways.

OBJECTIVES: This prospective, randomized, double-blind study was designed to determine the clinical efficacy and hemodynamic effects of different concentrations and equivalent volumes of levobupivacaine ERK inhibitor in epidural anesthesia. To our knowledge, this is the first study to evaluate the effects of concentration lower than 0.5% levobupivacaine.

METHODS: Forty adult patients with an American Society of Anesthesiology (ASA) I-III physical status undergoing transurethral endoscopic surgery were

randomly divided into 2 groups to receive either 10 mL of isobaric levobupivacaine (0.5% + 5 mL 0.9% saline [group 1; n = 20]) or 10 mL of isobaric levobupivacaine (0.75% + 5 mL saline 0.9% saline [group 2; n = 20]) for epidural anesthesia. An observer blinded to group division evaluated the time of onset, maximum level, and time to 2-segment regression of sensory block.

RESULTS: There were no differences between the 2 groups in terms of hemodynamic parameters and time of onset of the sensory block. There were significant differences, however, between the 2 groups in the maximum level of the sensory block (group 1, T9; group 2, T8; P = 0.010) and the time to 2-segment regression of sensory block (group 1, 46.35 minutes; group 2, 62.94 minutes; P = 0.013).

CONCLUSION: This study indicated that 10 mL of 0.5% levobupivacaine plus 5 mL of 0.