These mutations are known to be associated with variations in plasma MBL levels. Genotype frequencies were estimated by AZD8186 gene counting and were compared to the expectation of Hardy-Weinberg equilibrium by chi-squared (X (2)) analysis and Fisher’s exact test. Allele and genotype frequencies were compared in cases and controls using X (2) contingency table analysis.
There was no difference
in demographics between cases and controls. The number of miscarriages in the participants with RPL ranged from 2 to 10 spontaneous abortions (SAB’s) per participant. Populations genotyped were in Hardy-Weinberg equilibrium. There was no association between a history of RPL and multi-SNP genotypes at the MBL locus. In unexplained RPL, the number of SAB’s and live birth rates were unaffected by MBL genotype. There was no association between MBL genotype and the risk of unexplained RPL.
The occurrence of live birth was not associated with MBL genotype.
Genotypes known to cause low MBL plasma levels are not associated with an increased risk of unexplained RPL.”
“Background: This study aimed to evaluate the reliability and validity of two self-report physical activity (PA) questionnaires – the AQuAA (Activity Questionnaire for Adults and Adolescents) and PASE (Physical Activity Scale for the Elderly) – in cancer patients.
Methods: Test-retest reliability was determined by administering the questionnaires twice within 5 days. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and smallest C188-9 research buy detectable difference (SDD) were calculated. Construct validity was determined by comparing the questionnaire results with ActiGraph accelerometer scores using Spearman correlation coefficients (r(s)) and ICCs. Content validity was examined using the Three-Step Test-Interview (TSTI).
Results: Reliability for the AQuAA scores were fair to excellent (ICC = 0.57 to 0.78). Reliability for the PASE scores ranged from good to excellent (ICC = 0.67 to 0.90).
Correlations between the ActiGraph and the AQuAA and the PASE were low (r(s) = 0.05 and 0.16 respectively, and ICC = -0.001 to 0.44). The TSTI showed that participants experienced difficulties with the examples provided with the questions, the perceptions selleckchem of intensity level of PA, and with recalling the time spent on PA.
Conclusions: Both questionnaires showed good to excellent test-retest reliability for most scores. Construct validity of both questionnaires was low, as indicated by the low correlations with the ActiGraph. Except for a few difficulties that participants perceived when filling out the questionnaires, the content validity of both questionnaires was good.”
“In the present study, we investigated the histological, immunohistochemical and ultrastructural characteristics of cytoplasmic blood plasma inclusions that spontaneously occurred in a rat liver.