This Alpelisib avenue of research is still in its infancy, and research is needed to resolve problems of the current assay, including interferences from other compounds in the complex sample matrix which may induce a non taste-receptor mediated response by the cells [67]. There is currently a dearth of information on the taste attributes of bioactive protein hydrolysates or peptides. Research applying sensomics mapping, instrumental taste sensing

or cell-based systems to the study of bioactive peptides could accelerate the acquisition of important knowledge in this field. Bioactive peptides and protein hydrolysates hold great promise as valuable functional ingredients

in healthy diets to fight the global epidemic of non-communicable Gemcitabine mouse diseases. However, in order to realize this potential, several challenges must be addressed (Table 2). The high cost and multi-step nature of existing processes for bioactive peptide production implores the need to apply a systematic approach for identifying the best conditions to release ‘cryptides’ with target bioactivity from the parent protein source, and for developing innovative production and purification strategies to obtain peptide fractions with high potency and yield. Bioinformatics tools may be useful to guide the empirical approach and may also provide a better understanding at the molecular level of the peptide structure–activity relationship. Standardized methodology for analysis and robust clinical trials to evaluate efficacy and metabolic fate of the established products are of critical importance for quality assurance and justification of health claims. Finally, research must be conducted on the taste and other sensory quality attributes of bioactive peptides to ensure their successful adoption as functional

food ingredients that can lead to better health. Fossariinae Papers of particular interest, published within the period of review, have been highlighted as: • of special interest Financial support in the form of a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC RGPIN 121822-11) is gratefully acknowledged. “
“Current Opinion in Food Science 2015, 1:xx–yy This review comes from a themed issue on Food chemistry and biochemistry Edited by Delia B. Rodriguez Amaya doi:10.1016/j.cofs.2014.09.003 S2214-7993/© 2014 Elsevier Ltd. All rights reserved. The human sense of smell is triggered by small, non-polar to medium polar molecules which dock onto receptor proteins of the olfactory epithelium. They signal freshness, quality and authenticity of a food, hence guiding our choice of food.