Unfortunately, there is little data about the mineral composition and the antioxidant, mutagenic and antimutagenic activities of grape juice in eukaryote cells. We evaluated the mineral contents (Mg, Ca, Mn, Fe, Cu, Zn, Si, S, Cl) of grape juices, the antioxidant, CAL-101 nmr mutagenic and/or antimutagenic activities of the juices in the yeast Saccharomyces cerevisiae, and looked

for a possible association between mineral content and antioxidant, mutagenic and/or antimutagenic activities of juice samples. Eight commercial grape juices, four purple (Bordo variety) and four white (Niagara variety), were evaluated. Most of the minerals were in similar concentrations in purple and white grape juices, except for LY3039478 ic50 calcium and copper; purple grapes had more calcium content and white grapes had more copper content. All grape juices had important antioxidant and antimutagenic activities in S. cerevisiae and prevented the oxidative damage provoked by hydrogen peroxide (P < 0.05). Positive correlations (P < 0.05) were observed between antioxidant and antimutagenic activities and mineral content. In this context, we concluded that the grape juices, white

and purple, are an important mineral source, and these contents explain, in part, the important antioxidant and antimutagenic activities.”
“Background: At primary care facilities in Nigeria, national treatment guidelines state that malaria should be symptomatically diagnosed and treated with artemisinin-based combination therapy (ACT). Evidence from households and health care providers indicates that many patients do not receive AZD7762 molecular weight the recommended treatment.

This study sought to determine the extent of the problem by collecting data as patients and caregivers leave health facilities, and determine what influences the treatment received.

Methods: A cross-sectional cluster survey of 2,039 respondents exiting public health centres, pharmacies and patent medicine dealers was undertaken in urban and rural settings in Enugu State, south-eastern Nigeria.

Results: Although 79% of febrile patients received an anti-malarial, only 23% received an ACT. Many patients (38%) received sulphadoxine-pyrimethamine (SP). A further 13% of patients received an artemisinin-derivative as a monotherapy. An estimated 66% of ACT dispensed was in the correct dose. The odds of a patient receiving an ACT was highly associated with consumer demand (OR: 55.5, p < 0.001).

Conclusion: Few febrile patients attending public health facilities, pharmacies and patent medicine dealers received an ACT, and the use of artemisinin-monotherapy and less effective anti-malarials is concerning.