We found that age and regional white matter integrity differentially influenced cognitive performance. Age-related degradation in anterior Selisistat brain areas

was associated with decreased processing speed and poorer working memory, whereas reduced inhibition and greater task switching costs were linked to decline in posterior areas. Poorer episodic memory was associated with age-related differences in central white matter regions. The observed multiple dissociations among specific age-sensitive cognitive skills and their putative neuroanatomical substrates support the view that age-related cognitive declines are unlikely to stem from a single cause. (C) 2009 Elsevier Ltd. All rights reserved.”
“Objectives: Sternal instability after cardiac surgery occurs infrequently but can be challenging to manage. The most common treatment of mechanical sternal instability is operative rewiring. Transverse rib-to-rib stabilization with titanium plates designed for sternal fixation is a recent option. We evaluated the clinical utility of the transverse GSK3326595 manufacturer plating system in a cardiothoracic practice.

Methods: We retrospectively reviewed our experience with transverse sternal plating using the Synthes titanium sternal plate system (Synthes CMF, Paoli, Pa) from June 2004 to June 2007.

Results: There were 15 sternal reconstruction procedures performed

in 14 patients using the transverse sternal plates. One patient required reoperation for sternal plate fracture. Indications for sternal plating were chronic sternal dehiscence in 9 procedures, acute sternal dehiscence in 3 procedures, previous mediastinitis and sternectomy in 2 procedures, and sternal plate fracture in

1 procedure. The initial cardiac operation was isolated coronary artery bypass in all patients. The mean age was 59 years (range, 51-68 years), Non-specific serine/threonine protein kinase all patients were men, 12 patients had a body mass index of greater than 30 kg/m(2) (range, 22-40 kg/m(2)), 9 patients were diabetic, 8 patients were active smokers, and 7 patients had chronic obstructive pulmonary disease. The mean follow-up period was 15.5 months (range, 3-33 months). All patients achieved sternal stability with minimal postoperative pain. Complications included infection requiring explantation in 1 patient, plate fracture in 1 patient, and seroma formation in 1 patient.

Conclusion: The transverse sternal plating system successfully achieved stability in all cases and is valuable in complex sternal reconstructions. Sternal plating is an effective alternative to wire closure in sternum with fractures, chronic and acute instability, or poor bone quality.”
“Bilateral cochlear implants (CI) offer a unique opportunity for the study of spatial hearing plasticity in humans.